The overall goal of work in our laboratory is to understand the biology, genetics and genomics of mosquito vector diseases such as Malaria, arboviral related diseases, Lymphatic filariasis, and investigating mechanisms involved in insecticide resistance in Anopheles and Aedes vectors.
Randomised cluster control trials conducted in Benin and Tanzania provide compelling evidence of the epidemiological impact of using dual active ingredient insecticide-treated nets (dual AI ITNs) treated with chlorfenapyr (CFP)…
This study investigates the link between climate variations and the dynamics of antibiotic-resistant bacteria (ARB) in maternity wards in Burkina Faso and Cameroon. Focusing on antibiotic-resistant pathogens such as Extended-Spectrum Beta-Lactamase (ESBL)-producing Escherichia coli, Klebsiella pneumoniae, and methicillin-resistant Staphylococcus…
RAFT is a six-year multi-disciplinary global health research programme led by the London School of Hygiene & Tropical Medicine (LSHTM) working with partners in Cote d’Ivoire, Cameroon, Tanzania and Thailand…
The African Centre for Vector Genomics (AVecGen) is a transformative, 36-month initiative designed to establish Africa’s premier centre of excellence in vector genomics. Anchored at the Centre for Research in…
The goal of this project is to use population genomic methods/tools to evaluate the history and spread of the Anopheles stephensi population in non-endemic countries of Central Africa and Nigeria…
Despite significant progress in malaria control through improved treatment and vector control measures since the 2000s, recent years have witnessed a concerning stall due to the increasing prevalence of drug…
Malaria remains a devastating disease in the World (nearly 1/2 of the world population at risk) and particularly in Africa where more than 95% of cases are occurring. Prevention still…
This project is funded by the Commonwealth & Development Office (FCDO) under the RAFT consortium directed by Professors Sian Clark and Joe Lines, for £60,000. Launched in January 2024, the…
This is a Project funded by the Bill and Melinda Gates Foundation to the Centre for Research in Infectious Diseases (CRID) with aims at supporting capacity-building efforts in malaria mathematical…
As mosquitos have become resistant to chemicals used in sprays and bed nets, these methods are not as effective at killing mosquitoes as they once were. In order to identify…
Unless insecticide resistance is properly managed, the recent gains in reducing malaria transmission could be lost. Worrying cases of high resistance levels to insecticides are emerging in major malaria vectors…
In malaria vector control surveillance, data concerning many important indicators can only be collected via laboratory-based molecular tests (i.e., species confirmation of species complexes, molecular mechanisms of resistance, Plasmodium infectivity).…
In the major malaria vectors including An. funestus and An. gambiae metabolic mechanisms are driving resistance to most insecticides, including pyrethroids. But, contrary to target-site resistance such as knockdown resistance…
Worrying cases of high resistance levels to insecticides are emerging in major malaria vectors such as Anopheles funestus leading to extensive loss of efficacy of Long Lasting Insecticidal Nets (LLINs)…
COMAL (Co-Infection Plasmodium Malariae) This project aims to fully characterize the P. malariae parasites which is the least studied of the Plasmodium parasites and often reported as a benign malaria…
Mosquitoes that transmit malaria are becoming increasingly resistant to insecticides used to kill them. However, we still do not know if in addition to the ability to withstand insecticide exposures,…
About 90% of all malaria deaths in the world occur in sub Saharan Africa where resistance to antimalarial drugs and to most classes of insecticides are major obstacles for disease…
Malaria disease is caused by Plasmodium parasite transmitted during Anopheles mosquito blood feeding. Mosquito blood feeding is facilitated by the pharmacologic and immunologic properties of salivary proteins which counteract and…
Project Summary: Anopheles mosquito blood feeding is facilitated by the pharmacologic and immunologic properties of salivary bioactive molecules which counteract and inhibit host reaction. These bioactive molecules can also strongly…
There is limited information on the current distribution of Aedes spp. mosquitoes in Cameroon. Aedes albopictus was detected in five Southern Cameroon towns in 2000 and a temporal distribution of…
Aedes aegypti and Ae. albopictus are the main vectors of arboviruses’ diseases such as dengue, zika and chikungunya. Ae. aegypti is indigenous in Central Africa, whereas Ae. albopictus, originating from…
We encourage scientists to use an interdisciplinary approach in their research. We also aim to broaden the scope of expertise at the CRID or establish collaboration with scientists with expertise…
We are working to broaden the scope of research activities at CRID including Basic research (T1), Development (T2), Implementation (T3) and Monitoring and surveillance plus policy (T4). We aim to…
Accelerating Malaria Elimination Efforts In The Sahelian Region In Africa: Elucidation Of Factors Driving Transmission And Unraveling The Molecular Basis Of Insecticide Resistance In The Major Malaria Vectors.