PUBLICATION: “Long-term impact of exposure to Royal Guard, a pyriproxyfen-based bed net, on pyrethroid-resistant malaria vectors from Cameroon using DNA-based metabolic resistance markers” by Sonia Ngongang & al

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  The increasing pyrethroid resistance in malaria vectors underscores the need for control tools using non-pyrethroid molecules. This study assesses the efficacy of Alpha cypermethrin + pyriproxyfen, the dual active ingredient (ai) used in Royal Guard net, focusing on its long-term effects on mosquito life traits.  Cone tests showed low efficacy of Royal Guard on…

PUBLICATION: “Two highly-selected mutations in the tandemly duplicated CYP6P4a and CYP6P4b genes drive pyrethroid resistance in Anopheles funestus in West Africa”, by Nelly Manuela Tchatchoua & al 

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This study combines computational analysis and functional genomics experiments to provide in-depth insights into the molecular mechanisms by which the duplicated CYP6P4a and CYP6P4b genes are driving pyrethroid resistance in Anopheles funestus. Genotype-phenotype association studies were also used to assess the impact of these genes on the effectiveness of current vector control tools.  Two key…