Background
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Professor Cyrille Ndo is a parasitologist and vector biologist. He is the Head of the Department of Parasitology and Microbiology at the Centre for Research in Infectious Diseases (CRID) and a Wellcome Trust International Intermediate fellow. Prof. Ndo has obtained his PhD in 2011 at the University of Yaoundé in Cameroon on the bionomics and population genetics of Anopheles moucheti and Anopheles nili, two important malaria vectors in forested Africa. He subsequently completed a post-doctoral work on Anopheles arabiensis at the Insect Pest Control Laboratory at the International Atomic Energy Agency (Austria) developing the sterile insect technique for malaria vector control. In 2012, he moved to the Department of Ecology and Evolutionary Biology of the University of California Irvine (USA) as a postdoctoral researcher to study the evolution of chromosomal inversions in this species. In 2014, he was granted a Wellcome Trust training fellowship to study interactions between Anopheles funestus and Plasmodium falciparum parasite in the context of metabolic insecticide resistance. He also received funding (in 2017) from the World Health Organization to investigate impact of housing improvement as supplementary malaria vector control strategy in rural forested areas of Central Africa. Moreover, since 2014, Prof Ndo has regularly led research coordinated projects funded by the International Atomic Energy Agency working on development of the Sterile Insect Technique against the malaria vector Anopheles arabiensis. |
Research:
Prof Ndo’s research primarily focus on the biology of vector borne diseases, especially malaria. His current works aim at characterizing insecticide resistance in Anopheles vector populations and its impact on malaria transmission. Under his Wellcome Trust International Intermediate Fellowship, he is investigating if and how insecticide resistance affects Plasmodium development in Anopheles vector hosts, using transcriptomic and genomic (microarrays, RNAseq, RNAi) approaches.
- Areas of interest:
Anopheles biology, Anopheles genetics and genomics, Insecticide resistance, vector-parasite interactions, new and innovative vector control tools
- PhD students
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Past Phd students – Dr Kopya Edmond Phd defended in 2021 University of Yaoundé I, Cameroon – Dr Yacouba Poumachu PhD defended in 2021 University of Dschang, Cameroon Present PhD students – Danale Metitsi 3rd year University of Yaoundé I, Cameroon – Dominique Mieguim University of Yaoundé I, Cameroon – Salomon Efa 2nd year University of Yaoundé I, Cameroon – Darus Tagne, 2nd year University of Douala, Cameroon – Steve Joko 2nd year University of Dschang, Cameroon |
- OTHER RELEVANT EXPERTISE, PROFESSIONAL MEMBERSHIPS
– Honorary Fellow at the Liverpool School of Tropical Medicine
– Leading member of the Technical Vector Control Advisory Group of Cameroon
– Member of the Vector Control Committee at the National Malaria Control Programme (MOH)
– Member of the Cameroonian Society of Parasitology
– Member of the Panafrican Mosquito Control Association (PAMCA)
- PUBLICATIONS
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- Suh, P.F., Elanga-Ndille, E., Tchouakui, M. et al. Impact of insecticide resistance on malaria vector competence: a literature review. Malar J 22, 19 (2023). https://doi.org/10.1186/s12936-023-04444-2
- Efa S, Elanga-Ndille E, Poumachu Y, Tene B, Mikande JZ, Zakariaou N, Wondji CS, Ndo C. Insecticide Resistance Profile and Mechanisms in An. gambiae s.l. from Ebolowa, South Cameroon. Insects. 2022; 13(12):1133. https://doi.org/10.3390/insects13121133
- Ndo C, Elanga-Ndille E, Cheteug G, Metitsi RD, Wanji S, Moukoko CEE. IgG antibody responses to Anopheles gambiae gSG6-P1 salivary peptide are induced in human populations exposed to secondary malaria vectors in forest areas in Cameroon. PLoS One. 2022 Nov 10;17(11):e0276991. doi: 10.1371/journal.pone.0276991. PMID: 36355922; PMCID: PMC9648791.
- Agonhossou R, Akoton R, Dossou YA, Avokpaho E, Mbama DNJ, Boussougou-Sambe TS, Francis NN, Ndo C, Ntoumi F, Wondji CS, Adegnika AA, Borrmann S, Issifou S, Djogbénou LS. Surveillance of Plasmodium malariae infection among inhabitants of rural areas in Ouidah-Kpomasse-Tori Bossito health district, Benin. Parasitol Res. 2022 Jan;121(1):275-286.
- Kopya, E., Ndo, C., Djamouko-Djonkam, L., Nkahe, L., Awono-Ambene, P., Njiokou, F., Sinclair Wondji, C. and Antonio-Nkondjio, C. Anopheles leesoni Evans 1931, a Member of the Anopheles funestus Group, Is a Potential Malaria Vector in Cameroon. Advances in Entomology 2022. 10, 99-109.
- Vivek Jayaswal, Cyrille Ndo, Hsiu-Ching Ma, Bryan D Clifton, Marco Pombi, Kevin Cabrera, Anna Cohuet, Karine Mouline, Abdoulaye Diabaté, Roch Dabiré, Diego Ayala, José M Ranz, Intraspecific Transcriptome Variation and Sex-Biased Expression in Anopheles arabiensis. Genome Biology and Evolution 2021, Volume 13, Issue 9.
- Mieguim Ngninpogni D, Ndo C, Ntonga Akono P, Nguemo A, Nguepi A, Metsiti DR, Tombi J, Awono-Ambene P, Bilong Bilong CF. Insights into factors sustaining persistence of high malaria transmission in forested areas of sub-Saharan Africa: the case of Mvoua, South Cameroon. Parasites Vectors 2021, 14: 2.
- Nouage L, Elanga-Ndille E, Binyang A, Tchouakui M, Atsatse T, Ndo C, Kekeunou S, Wondji CS. Influence of GST- and P450-based metabolic resistance to pyrethroids on blood feeding in the major African malaria vector Anopheles funestus. PLoS ONE 2020, 15(9): e0230984
- Nkemngo FN, Mugenzi LMJ, Terence E, Niang A, Wondji M, Tchoupo M, Ngiffo Nguete D, Tchapga W, Irving H, Mbama Ntabi JD, Agonhossou R, .Boussougou- Sambe Terence S, Akoton R B, Koukouikila-Koussounda Felix, PinillaYudi, Ntoumi Francine, . Djogbenou LS, Ghogomu S M, Ndo C, Adegnika AA. Multiple insecticide resistance and Plasmodium infection in the principal malaria vectors Anopheles funestus and Anopheles gambiae in a forested locality close to the Yaoundé airport, Cameroon. Wellcome Open Research 2020, 5:146.
- Elanga-Ndille E, Binyang A, Ndo C, Assatse T, Nouage L, Tchouakui M, Tene-Fossog B, Kekeunou S, Wondji CS. Entomological indicators of malaria transmission and insecticide resistance profile of Anopheles gambiae at the early phase of irrigated rice farming in the forest area of central Cameroon. Wellcome Open Res 2020, 5:190
