Background
| Tepa Njiguet Gabin Arnaud is a PhD Research Fellow at the Centre for Research in Infectious Diseases , where his work focuses on unraveling the molecular mechanisms of insecticide resistance in malaria vectors. His research contributes to advancing strategies for malaria control by bridging molecular insights with public health applications. Prior to his doctoral fellowship, Arnaud built extensive professional experience as a Laboratory Scientist and Consultant across multiple medical laboratories. In these roles, he developed strong expertise in molecular diagnostics, quality control, and laboratory management, ensuring high standards of accuracy and reliability in clinical and research settings. Arnaud’s academic journey reflects a solid foundation in the life sciences: • Master’s in Molecular Biosciences (2018) • Master’s in Health Sciences – Immunology (2015) • Bachelor in Biology of Animal Organisms (2012) Through this blend of academic training and professional practice, Arnaud has established himself as a skilled researcher and laboratory professional, committed to advancing molecular biology and its applications in infectious disease research and public health. |
Research
Arnaud Tepa’s research centers on deciphering the genetic and molecular mechanisms underlying insecticide resistance in Anopheles gambiae, the primary malaria vector in Africa. His work integrates transcriptomic and genomic approaches to identify the key drivers of resistance, providing insights that are critical for sustaining the effectiveness of vector control strategies.
A major component of his research involves the functional validation of candidate genes and single nucleotide polymorphism (SNP) associations linked to resistance phenotypes. By bridging molecular findings with experimental validation, he contributes to a deeper understanding of how genetic variation shapes resistance and impacts malaria transmission dynamics.
Beyond his core research, Arnaud is strongly committed to capacity building in molecular biology and bioinformatics across Africa. He actively engages in knowledge transfer and training initiatives, aiming to strengthen local expertise and empower African scientists to lead advanced genomic research in public health.
- Areas of interest:
| · Insecticide resistance in malaria vectors
· Vector genomics and transcriptomics · Molecular diagnostics and bioinformatics · Public health entomology |
Other Relevant Expertise, Professional Memberships
– Project development and capacity building
- Research groups
Wondji Research Unit (WoRu)
- Supervisor
Prof. Wondji Charles -
Publications
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1. Tepa, A.; Kouamo, M.; Kengne-Ouafo, J.A.; Tchouakui, M.; Pieme, C.A.; Wondji, C.S. Insights from Transcriptomic Profiling Identify the CYP6Z Gene Family as Key Drivers of Pyrethroid Resistance Escalation in Anopheles Gambiae from Cameroon 2025. 2. Sankhe, S.; Fofana, F.G.; Heiba, W.; Ogunyemi, O.M.; Masisi, K.; Muiruri, I.; Abaah, E.A.; Tepa, A.; Fru, C.T.; Johnson, J.T.; et al. BioStruct-Africa’s Capacity Building Workshops as a Model for Advancing the Emerging Community of Structural Biologists in Africa. Commun. Chem. 2025, 8, 118, doi:10.1038/s42004-025-01519-w.
3. Tchoupe, E.B.; Kameni, M.N.; Eric, M.B.; Taya, J.B.; Kamdem, S.D.; Nkah, L.N.; Moor, V.A.; Tepa, A.; Neba, F.R.; Awuah, A.A.-A.; et al. Investigating the Potential of Clinical Variables and Ace2/Tmprss2 Genetic Variants as a Biomarkers for COVID-19 and Malaria Co-Infection in Cameroon 2025, 2025.08.01.25332654. https://www.medrxiv.org/content/10.1101/2025.08.01.25332654v1
4. Chatue, I.A.D.; Nyegue, M.A.; Kamdem, S.D.; Taya-Fokou, J.B.; Djiyou, A.B.D.; Tchoupe, E.B.; Tepa, A.; Neba, R.F.; Junaid, I.T.; Malhotra, P.; et al. Impact of Epstein-Barr Virus Reactivation on Cytokine Levels in Pregnant Women with Malaria in the West Region of Cameroon. Sci. Rep. 2025, 15, 33976, doi:10.1038/s41598-025-10846-w.
5. Kameni, M.N.; Tchoupe, E.B.; Kamdem, S.D.; Bhalla, N.; Assam Assam, J.P.; Tepa, A.N.; Neba, F.R.; Nanda, R.K.; Awuah, A.A.-A.; Amuasi, J.H.; et al. Mutations in Ace2 Gene Modulate Cytokine Levels and Alter Immune Responses in Mycobacterium Tuberculosis and SARS-CoV-2 Co-Infection: A Cameroonian Cohort. Front. Immunol. 2025, 16, doi:10.3389/fimmu.2025.1533213.
6. Tchouakui, M.; Djoko Tagne, C.S.; Tazokong, H.R.; Kengne Ouafo, J.A.; Kouamo, M.; Fofie, D.; Tepa, A.; Wondji, M.; Ibrahim, S.S.; Wondji, C.S. A COEAE80 Esterase Variant and P450-Suppression Drive Chlorfenapyr Resistance in Malaria Vectors 2025.
7. Kengne-Ouafo, J.A.; Kouamo, M.; Muhammad, A.; Tepa, A.; Ntadoun, S.; Mugenzi, L.; Tekoh, T.; Hearn, J.; Tchouakui, M.; Wondji, M.; et al. A Single E205D Allele of a Key P450 CYP6P3 Is Driving Metabolic Pyrethroid Resistance in the Major African Malaria Vector Anopheles Gambiae 2024, 2024.02.18.580859.
8. Voufo, R.A.; Kouotou, A.E.; Tatah, N.J.; TeTo, G.; Gueguim, C.; Ngondé, C.M.E.; Njiguet Tepa, A.G.; Amazia, F.; Yembeau, N.L.; Kouanfack, C.; et al. Relation between Interleukin-6 Concentrations and Oxidative Status of HIV Infected Patients with /or at Risk of Kaposi Disease in Yaounde. Virol. J. 2023, 20, 165, doi:10.1186/s12985-023-02109-9.
9. Tepa, A.; Kengne-Ouafo, J.A.; Djova, V.S.; Tchouakui, M.; Mugenzi, L.M.J.; Djouaka, R.; Pieme, C.A.; Wondji, C.S. Molecular Drivers of Multiple and Elevated Resistance to Insecticides in a Population of the Malaria Vector Anopheles Gambiae in Agriculture Hotspot of West Cameroon. Genes 2022, 13, 1206, doi:10.3390/genes13071206.
10. Tepa, A.G.N.; Ambassa, P.; Ayong, L.S.; Biapa Nya, P.C.; Pieme, C.A. The Antiplasmodial Potential of Medicinal Plants Used in the Cameroonian Pharmacopoeia: An Updated Systematic Review and Meta-Analysis. Evid.-Based Complement. Altern. Med. ECAM 2022, 2022, 4661753, doi:10.1155/2022/4661753.
11. Flore, F.A.; Beactrice, N.N.; Francine, T.N.; Sebatien, K.; Arnaud Gabin, T.N.; Proper Cabral, B.N.; Anatole, P.C. A Study on the Phytochemical Composition and Potential Benefits of Syzygium Guineense Wild (Guineense): An Overview. Glob. J. Med. Res. 2022, 11–29, doi:10.34257/LJMHRVOL22IS12PG11.
12. Tepa, A.; Abame, I.; Makamta, V.; Fongang, B.; Donkeu, J.; Ayong, L.; Pieme, C.A. Nutritional Status and Humoral Immune Response to Plasmodium Falciparum in Children Aged 6–59 Months. J. Trop. Med. 2020, 2020, doi:10.1155/2020/1843780.
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