DR. GLAWDYS CHETEUG

Background

Dr Gladys Cheteug is a Post-doctoral Research Assistant at CRID under the International Centers of Excellence for Malaria Research (ICEMR) Project, funded by NIH. He obtained her Ph.D in Cellular and Molecular Parasitology at the University of Buea, Cameroon in June 2023. Prior to this, she performed Master Research in Tropical Infectiology at the “Ecole Doctorale Régionale d’Afrique Centrale”, Franceville-Gabon in October 2017. Before that, she had obtained a Master in Health Sciences, Major: Immunology at the Catholic University of Central Africa, Cameroon in December 2014. Gladys Cheteug obtained her bachelor’s degree in Biochemistry at the University of Yaoundé I, Cameroon in the month of September 2010 

Before joining CRID in 2024, she worked in the Malaria Research Unit of Centre Pasteur Cameroun for one year. There, she tackled Research Consulting in Cell Culture of P. falciparum and focused on the Development of an in vitro cell culture protocol for P. falciparum clinical isolates. Previously, she had done her Master and PhD Academic internship there, with her thesis entitled: “Validation of Anopheles salivary biomarker to assess human exposure to anopheles bites and the efficacy of vector control strategies in Cameroon”. From October 2015 to March 2016, she worked on “PALEVALUT-Project”, still at Centre Pasteur Cameroun. She performed field epidemiologic work and research on malaria. This included blood sample collection, preparation of equipment and reagents, daily report of field activities, database registration and computerization.

During the year 2014, she did her Master internship in Health Sciences at “Fondation Chantal Biya”. Her role consisted in monitoring HIV children under ARV Therapy, counselling, data screening, quality assurance, monitoring the occurrence of immune reconstitution inflammatory syndrome (IRIS) in children under ARV-T. She designed a Biostatistics plan and performed data collection, analysis, and interpretation using epi-info and spss software.

Research:

Parasitic immunology, P. falciparum cultures (clinical isolates and laboratory strains), collection of larvae and adult mosquitoes, experimental infections of Anopheles coluzzii, by direct membranes feeding from the blood of gametocyte carriers, mosquito rearing, dissection of stomachs and saliva gland for the identification of oocysts and sporozoites.

• Areas of interest:

Parasitic immunology, P. falciparum cultures (clinical isolates and laboratory strains), collection of larvae and adult mosquitoes, experimental infections of Anopheles coluzzii, by direct membranes feeding from the blood of gametocyte carriers, mosquito rearing, dissection of stomachs and saliva gland for the identification of oocysts and sporozoites.

• Research – an overview of  your research areas(s)
  

Immunology:  Dr Cheteug is interested in understanding how the human body responds to foreign substances and pathogens in order to assess the immunological profile in terms of specific antibodies, expression of cellular markers and the association with the outcome of disease. She uses specific antibody responses as immune biomarkers to assess the efficacy and effectiveness of tools used as vectors control in the fight against vectors borne diseases and also to evaluate the level of human exposure to some vectors.  

Parasitology:  Dr Cheteug studies parasite genomics by observing the parasite evolution, genetic diversity in order to understand the virulence of parasite genes and their discrimination in the population.  She also works in Plasmodium. falciparum cells cultures (clinical isolates and laboratory strains) that can be used in drug discovery. She aims to generate a bank of clinical isolates parasites from different localities.

Entomology: Dr Glwadys is involved in the collection of larvae and adult mosquitoes (dipping, indoor aspiration, human landing cashes, CDC light trap) and their identification, mosquito rearing: field and laboratory strain, experimental infections of Anopheles coluzzii by direct membranes feeding with the blood from P. falciparum gametocyte carriers, dissection of stomachs for the identification of oocysts.

• Other Relevent  Expertise, PROFESSIONAL MEMBERSHIPS
  

  Medical analysis technics Mastery Management and control quality of medical analysis labs Ensures quality control of slide and smear readings for malaria diagnosis as part of the performance evaluation of technicians in health districts throughout Cameroon on behalf of the National Malaria Control Programme. Monitoring of field epidemiological survey as well in the hospital and in the communities   Member of PAMCA Cameroon chapter Member of AMMnet Cameroon Member of ASCAMVECT (Cameroon mosquito control association) Member of SoCP (Societé Camerounaise de parasitologie)

• PhD students
  

  Eric NDUMU

• Publications

• • Utility of plasma anti-gSG6-P1 IgG levels in determining changes in Anopheles gambiae bite rates in a rural area of Cameroon.
    Glwadys Cheteug Nguetsa,et al., 2024: Scientific report.  https://doi.org/10.1038/s41598- 024-58337-8.10 publications to datea- Articles from my PhD thesis (o3)
  • IgG antibody responses to Anopheles gambiae gSG6-P1 salivary peptide are induced in human populations exposed to secondary malaria vectors in forest areas in Cameroon.

  C Ndo, E Elanga-Ndille, G Cheteug, RD Metitsi, S Wanji, CE Eboumbou MoukokoIg.  2022. PloS One journal

  https://ddoi.org/10.1371/journal.pone.0276991 

  • Preliminary validation of the use of IgGantibody response to Anopheles gSG6-p1 salivary peptide to assess human exposure to malaria vector bites in two endemic areas of Cameroon in Central Africa. G Cheteug et al.  PloS One journal https://doi.org/10.1371/journal.pone.0242510

  b- Articles in co-author (07)

  • Stage-Dependent Release of Plasmodium Falciparum Homolog of T-Cell Immunomodulatory Protein and Association of Plasma Levels with Suppression of Macrophage-Inflammatory Protein-1 Chemokine Production in Infected Individuals.

  Donkeu Christiane, Efange Noella1, Atchombat Derrick, Emoh Cynthia, Fogang Balotin, Biabi, Marie Florence, Mbianda Nana Chris Marco1, Essangui Estelle, Maloba Franklin, Cheteug Glwadys et al., 2025.  Journal of Immunology and Infectious Diseases

  • Asymptomatic carriage of Plasmodium falciparum in children living in a hyperendemic area occurs independently of IgG responses but is associated with a balanced inflammatory cytokine ratio.

  Balotin Fogang, Matthieu Schoenhals, Franklin M. Maloba Marie Florence Biabi, Estelle Essangui, christiane Donkeu, Glwadys Cheteug et al., 2024. Malaria journal.  https://doi.org/10.1186/s12936-024-05086-8

  • High Prevalence of Polyclonal Plasmodium falciparum Infections and Association with Poor IgG Antibody Responses in a Hyper-Endemic Area in Cameroon.
    MF A Bite Biabi, B Fogang, E Essangui, F Maloba, C Donkeu , R Keumoe, G Cheteug, N et al.,Trop Med Infect Dis. 

  https://doi.org/10.3390/tropicalmed8080390

  • Chemical composition and repellent activity of essential oils of Tithonia diversifolia (Asteraceae) leaves against the bites of Anopheles coluzzii.
    C Akeumbiwo Tchumkam, L P Kojom Foko , C Ndo, E Essangui Same ,G Cheteug Nguetsaet al.,  Scientifc Reports.  https://doi.org/10.1038/s41598-023-31791-6 
  • Clinical characteristics of Plasmodium falciparum infection among symptomatic patients presenting to a major urban military hospital in Cameroon.

  DZ Hodson , YMbarga Etoundi, N Mbatou Nghokeng, RM Poulibe, S Magne Djoko, J Goodwin, G Cheteug Nguesta et al., 2022. Malaria journal.  https://doi.org/10.1186/s12936 

  • High Prevalence of Asymptomatic Malarial Anemia and Association with Early Conversion from Asymptomatic to Symptomatic Infection in a Plasmodium falciparum Hyperendemic Setting in Cameroon.

  Fogang B, Biabi MF, Megnekou R, Maloba FM, Essangui E, Donkeu C, Cheteug G. et al., 2021. Trop Med Hyg.

    https://doi.org/10.4269/ajtmh.21- 0316.PMID:34724628 

  • Demographical, hematological and serological risk factors for Plasmodium falciparumgametocyte carriage in a high stable transmission zone in Cameroon.

  E Essangui, CE Eboumbou Moukoko, N Nguedia, M Tchokwansi, U Banlanjo, F Maloba, B Fogang, C Donkeu, M Biabi, G Cheteug el al. 2019. PloS One journal 

  https://doi.org/10.1371/journal.pone.021613 

• ADDITIONAL NOTES,

Dr Cheteug wishes to gain expertise on molecular epidemiology of Infectious diseases and the monitoring of randomize clinical trials.