PUBLICATION: Association of a rapidly selected 4.3kb transposon-containing structural variation with a P450-based resistance to pyrethroids in the African malaria vector Anopheles funestus By Leon Mugenzi, Theophelix Tekoh and al

News

Malaria remains a major health concern in Africa. One way we control malaria is by targeting the mosquitoes transmitting the disease using pyrethroid insecticides. These mosquitoes are however becoming resistant to these insecticides, making it harder to fight malaria. Understanding how these mosquitoes can survive insecticide exposure will help guide malaria vector control programs to…

PUBLICATION: The duplicated P450s CYP6P9a/b drive carbamates and pyrethroids cross-resistance in the major African malaria vector Anopheles funestus By Leon M. J. Mugenzi & al

News

Insecticide-based vector control measures are extensively used in the fight against malaria. Unfortunately, insecticides are in danger of losing their potency due to the development of resistance in vector species populations. The worst-case scenario is when a single resistance mechanism confers resistance to many insecticide classes, thereby hindering resistance management. Therefore, applying appropriate insecticide-based interventions…

PUBLICATION: Substrate promiscuity of key resistance P450s confers clothianidin resistance while increasing chlorfenapyr potency in malaria vectors By Magellan Tchouakui and al

News

Novel insecticides were recently introduced in public health by the World Health Organisation (WHO) to counter pyrethroid resistance threats in African malaria vectors. To prolong their effectiveness, potential cross-resistance from promiscuous pyrethroid metabolic resistance mechanisms must be elucidated. In our new paper in Cell Reports, Tchouakui et al used recently detected P450 DNA-based markers of…