Investigating impact of insecticide resistance and immune system on Plasmodium falciparum development in the major malaria vector Anopheles funestus in Cameroon

Projects

About 90% of all malaria deaths in the world occur in sub Saharan Africa where resistance to antimalarial drugs and to most classes of insecticides are major obstacles for disease control. In the absence of an effective vaccine, novel control strategies are therefore needed. Among the novel approaches being investigated is the replacement of mosquitoes…

Comparative analysis of salivary expressed proteins in insecticide resistant and susceptible wild strain of Anopheles funestus mosquito, major malaria vector in Africa.

Projects

Malaria disease is caused by Plasmodium parasite transmitted during Anopheles mosquito blood feeding. Mosquito blood feeding is facilitated by the pharmacologic and immunologic properties of salivary proteins which counteract and inhibit host reaction. These bioactive molecules can also strongly influence the salivary gland invasion by Plasmodium and their transmission during the blood feeding. It has…

Impact of insecticide resistance on mosquito’s sialome and it’s effect on vectorial capacity of main african malaria vectors

Projects

Project Summary: Anopheles mosquito blood feeding is facilitated by the pharmacologic and immunologic properties of salivary bioactive molecules which counteract and inhibit host reaction. These bioactive molecules can also strongly influence the salivary gland invasion by Plasmodium and their transmission during the blood feeding by counteracting human host reaction. It has been reported that salivary…