In the major malaria vectors including An. funestus and An. gambiae metabolic mechanisms are driving resistance to most insecticides, including pyrethroids. But, contrary to target-site resistance such as knockdown resistance (kdr) for which DNA-based markers have been detected for more than two decades, until of recent, no DNA-based molecular assays were available to easily track…
Worrying cases of high resistance levels to insecticides are emerging in major malaria vectors such as Anopheles funestus leading to extensive loss of efficacy of Long Lasting Insecticidal Nets (LLINs) including PBO-pyrethroid nets. Unless such super-resistance is managed, recent gains in reducing malaria transmission could be lost with terrible consequences. Unfortunately, the molecular drivers of…
The CRID seeks to appoint 01 Post-Doctoral Research Assistant to work with Dr Ndo on a Wellcome Trust funded project that aims to investigate impact of metabolic resistance to pyrethroids on the vectorial competence of Anopheles funestus using various approaches such as experimental infections, transcriptomic (RNAseq, Gene Ontology and KEGG Pathways analysis), and functional genomics (RNAi and qRT-PCR). The suitable…