Impact of metabolic resistance to pyrethroids on the vectorial competence of the major African malaria vector Anopheles funestus

Projects

Mosquitoes that transmit malaria are becoming increasingly resistant to insecticides used to kill them. However, we still do not know if in addition to the ability to withstand insecticide exposures, resistance mechanisms also influence the capacity of mosquitoes to allow malaria parasites to develop in them, preventing to fully assess the damages that such resistance…

Investigating impact of insecticide resistance and immune system on Plasmodium falciparum development in the major malaria vector Anopheles funestus in Cameroon

Projects

About 90% of all malaria deaths in the world occur in sub Saharan Africa where resistance to antimalarial drugs and to most classes of insecticides are major obstacles for disease control. In the absence of an effective vaccine, novel control strategies are therefore needed. Among the novel approaches being investigated is the replacement of mosquitoes…

Comparative analysis of salivary expressed proteins in insecticide resistant and susceptible wild strain of Anopheles funestus mosquito, major malaria vector in Africa.

Projects

Malaria disease is caused by Plasmodium parasite transmitted during Anopheles mosquito blood feeding. Mosquito blood feeding is facilitated by the pharmacologic and immunologic properties of salivary proteins which counteract and inhibit host reaction. These bioactive molecules can also strongly influence the salivary gland invasion by Plasmodium and their transmission during the blood feeding. It has…